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Nevertheless, readers should keep in mind that residual confounding may bias our estimates of some model inputs, including our indirectly tabulated estimates of the burden of tobacco-attributable illness (Supplementary file Section 1) and policy effectiveness derived from literature based, by necessity, on observational studies

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Although the additional IQOS MGOs will add to the small availability of FDA-authorized safer nicotine alternatives in the United States, they are also a reminder that the PMTA process favors well-financed manufacturers, mainly with ties to the tobacco industry